Director Shareholding

GlaxoSmithKline PLC
18 May 2005






                              Director's Interests

Following a re-valuation of the cash element of the notional investment held
within the US Retirement Savings Plan, which is notionally held in GSK Ordinary
Share ADRs, the Administrators of the Plan notified GlaxoSmithKline plc and the
under-mentioned Directors on 18 May 2005 of an increase in the notional
allocation of Ordinary Share ADRs on 12 May 2005 at a price of $49.95 per 
share:-


  Dr J P Garnier                            46
                                                                       
  Dr T Yamada                               16


S M Bicknell

Company Secretary

18 May 2005




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