Director Shareholding

GlaxoSmithKline PLC
18 May 2005




Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc:


The Administrators of the GlaxoSmithKline US Retirement Savings Plan ("the
Plan") notified GlaxoSmithKline plc on 18 May 2005, that as a result of a
movement in the fund on 12 May 2005, the number of Ordinary Share ADRs held by
the fund had changed from 18,168,570 to 18,264,444 at an average price of
$50.67.


The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Dr T Yamada are therefore potentially
interested in the shares held in the fund from time to time in the same way as
other employees or former employees of GlaxoSmithKline plc and its subsidiaries.




S M Bicknell

Company Secretary



18 May 2005


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