Director Shareholding

GlaxoSmithKline PLC
15 March 2005





                              Director's Interests

Following a re-valuation of the cash element of the notional investment held
within the US Retirement Savings Plan, which is notionally held in GSK Ordinary
Share ADRs, the Administrators of the Plan notified GlaxoSmithKline plc and the
under-mentioned Director on 15 March 2005 of an increase in the notional
allocation of Ordinary Share ADRs on 11 March 2005 at a price of $48.48 per
share:-



Dr T Yamada                              42


S M Bicknell
Company Secretary

15 March 2005




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