Director Shareholding

GlaxoSmithKline PLC
07 January 2005


                              Directors' Interests



The Administrators of the GlaxoSmithKline Executive Supplemental Savings Plan
notified the Company and the under-mentioned Directors on 07 January 2005 of
changes in their interests in Ordinary Share ADRs arising from an increase in
their interests under the Annual Investment Plan feature following the
re-investment of the dividend paid to shareholders on 06 January 2005 at a price
of $46.41 per share:-


Dr J P Garnier                                                  294.057

Dr T Yamada                                                     189.209



S M Bicknell

Company Secretary


7 January 2005








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