Director Shareholding

GlaxoSmithKline PLC
07 January 2005




                              Directors Interests


I give below details of a change in the interests in Ordinary Shares of
GlaxoSmithKline plc in respect of the under-mentioned Director arising from the
purchase of Ordinary Shares at a price of £12.37 per Ordinary Share on 06
January 2005 through the Company's ShareReward Plan ("the Plan") which Mr Coombe
entered on 5 October 2001:



Mr J D Coombe      Acquisition of 6 Ordinary Shares under the Dividend 
                   Reinvestment element of the Plan


Mr Coombe and the Company were advised of this information on 07 January 2005.







S M Bicknell
Company Secretary


7 January 2005


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