Director Shareholding

GlaxoSmithKline PLC
29 March 2005





                            Director's Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.




23 March 2005              The Administrators of the SmithKline Beecham Employee Benefit Trust ("The
                           Trust") notified the Company on 29 March 2005 that 375 Ordinary shares in the
                           Company had been sold on behalf of a participant in the GlaxoSmithKline Annual
                           Investment Plan at a price of £12.30 per share.



                           The Trust also notified the Company on 29 March 2005 that 1265 Ordinary shares
                           had been transferred from the Trust to a participant in the GlaxoSmithKline
                           Annual Investment Plan.






The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, John Coombe is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.




S M Bicknell
Company Secretary



29 March 2005




                      This information is provided by RNS
            The company news service from the London Stock Exchange