Director Shareholding

GlaxoSmithKline PLC
23 February 2005


Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


22 February 2005            Abacus (GSK) Trustees Limited, as trustee of the GlaxoSmithKline
                            Employee Trust, ("the GSK Trust"), transferred 113,190 Ordinary
                            Shares in the Company to participants in the SmithKline Beecham
                            Employee Share Option Plan 1991.



The Company was advised of these transactions on 23 February 2005.



The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J D Coombe are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.



S M Bicknell,

Company Secretary



23 February 2005


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