Director Shareholding

GlaxoSmithKline PLC 21 February 2005 Director's Interests I give below details of changes in directors' interests in the Ordinary Shares of GlaxoSmithKline plc. 18 February 2005 The Administrators of the SmithKline Beecham Employee Benefit Trust notified the Company on 21 February 2005 that 262 Ordinary shares in the Company had been sold on 18 February 2005 on behalf of a participant in the SmithKline Beecham Bonus Investment Plan at a price of £12.402 per share. The Trust also notified the Company on 21 February 2005 that 855 Ordinary shares had been transferred from the Trust to a participant in the SmithKline Beecham Bonus Investment Plan. The Trust is a discretionary fund of which all non US employees or former employees of GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. One of the Company's directors, John Coombe is therefore interested in the shares held in the fund from time to time in the same way as other non US employees or former employees of GlaxoSmithKline plc and its subsidiaries. S M Bicknell Company Secretary 21 February 2005 This information is provided by RNS The company news service from the London Stock Exchange

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