Director Shareholding

GlaxoSmithKline PLC
12 April 2005

                              Director's Interests


I give below details of a change in the interests in Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned Director arising from the
purchase of Ordinary Shares at a price of £12.24 per Ordinary Share on 11 April
2005 through the Company's ShareReward Plan ("the Plan") which Mr Heslop entered
on 5 October 2001:


Mr J S Heslop          Acquisition of 10 Ordinary Shares under the partnership 
                       element of the Plan (personal contribution)

                       Acquisition of 10 Ordinary Shares under the matching 
                       element of the Plan (Company contribution)


Mr Heslop and the Company were advised of this information on 12 April 2005.


S M Bicknell
Company Secretary

12 April 2005


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