Director Shareholding

GlaxoSmithKline PLC
11 April 2005





Director's Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.




06 April 2005              The Administrators of the SmithKline Beecham Employee 
                           Benefit Trust ("The Trust") notified the Company on 
                           11 April 2005 that 649 Ordinary shares in the
                           Company had been sold on behalf of a participant in 
                           the GlaxoSmithKline Bonus Investment Plan at a price 
                           of £12.28 per share.





The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Julian Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.







S M Bicknell
Company Secretary



11 April 2005




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