Director Shareholding

GlaxoSmithKline PLC
14 February 2005



                              Directors' Interests

I give below details of changes in directors' interests in the American
Depositary Shares of GlaxoSmithKline plc.
                         
11 February 2005         Abacus Corporate Trustee Limited, as trustee of the
                         GlaxoSmithKline US Trust, ("the GSK US Trust"), 
                         transferred 1,215 American Depositary Shares (ADSs) in 
                         the Company to participants in the GlaxoSmithKline 
                         Performance Share Plan.

The Company was advised of this transaction on 14 February 2005.

The GSK US Trust is a grantor trust of which all employees or former employees
of SmithKline Beecham Corporation and its subsidiaries are potential
beneficiaries.  Two of the Company's directors, Dr J-P Garnier and Dr T Yamada
are therefore interested in the shares held in the GSK US Trust from time to
time in the same way as other employees or former employees of SmithKline
Beecham Corporation and its subsidiaries.

S M Bicknell
Company Secretary

14 February 2004


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