Director Shareholding

GlaxoSmithKline PLC
09 December 2004



                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary and
American Depositary Shares of GlaxoSmithKline plc.


07 December 2004    Abacus (GSK) Trustees Limited, as trustee of the GSK Trust,
                    transferred 12,648 Ordinary Shares in the Company to
                    participants in the SmithKline Beecham Employee Share Option
                    Plan 1991.

08 December 2004    Abacus (GSK) Trustees Limited, as trustee of the
                    GlaxoSmithKline Employee Trust, ("GSK Trust"), converted
                    9,791,588 Ordinary shares in the Company into 4,895,794 ADSs
                    in the Company which were subsequently sold at a price of
                    US$43.73 per ADS.

                    Abacus Corporate Trustee Limited, as trustee of the
                    GlaxoSmithKline US Trust, ("the GSK US Trust"), purchased
                    4,895,794 American Depositary Shares (ADSs) in the Company
                    at a price of US$43.73 per ADS.

The Company was advised of these transactions on 08 December 2004.

The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J D Coombe are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.

The GSK US Trust is a grantor trust of which all employees or former employees
of SmithKline Beecham Corporation and its subsidiaries are potential
beneficiaries.  Two of the Company's directors, Dr J-P Garnier and Dr T Yamada
are therefore interested in the shares held in the GSK US Trust from time to
time in the same way as other employees or former employees of SmithKline
Beecham Corporation and its subsidiaries.

S M Bicknell
Company Secretary
09 December 2004


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