Director Shareholding

GlaxoSmithKline PLC
01 February 2005


                              Director's Interests

Following a re-valuation of the cash element of the notional investment held
within the US Retirement Savings Plan, which is notionally held in GSK Ordinary
Share ADRs, the Administrators of the Plan notified GlaxoSmithKline plc and the
under-mentioned Directors on 1 February 2005 of an increase in the notional
allocation of Ordinary Share ADRs on 28 January 2005 at a price of $44.81 per
share:-

Dr J P Garnier                                                         79
Dr T Yamada                                                            13


S M Bicknell
Company Secretary
1 February 2005


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