Director Shareholding

GlaxoSmithKline PLC
04 January 2005


                              Directors' Interests


I give below details of changes in the directors' interests in the Ordinary
Shares and American Depository Shares (ADSs) of GlaxoSmithKline plc.

On 31 December 2004, the following Non-Executive Directors were provisionally
allocated the following awards over Ordinary Shares and American Depository
Shares (ADS's) in the Company through the Annual Re-investment of Dividends paid
throughout 2004, as listed below:

SmithKline Beecham Non-Executive Directors Retainer Fee and Share Allocation
Award - Annual Dividend Reinvestment


Non-Executive Director                No. of Ordinary  Average Price (£) No. of ADS's     Average Price
                                      Shares                                              ($)

Sir Christopher Hogg                  34.848           12.22
Sir Ian Prosser                       34.848           12.22
Dr Lucy Shapiro                       56.623           12.22             16.007           47.41





GlaxoSmithKline Non-Executive Directors Automatic Share Award and Elected Share
Award - Annual Dividend Reinvestment


Non-Executive Director                No. of Ordinary  Average Price (£) No. of ADS's     Average Price
                                      Shares                                              ($)

Sir Christopher Hogg                  1,033.638        12.22
Sir Christopher Gent                  3.562            12.22
Mr Lawrence Culp                                                         44.205           47.41
Mr Crispin Davis                      103.034          12.22
Sir Peter Job                         451.575          12.22
Sir Ian Prosser                       294.489          12.22
Dr Ronaldo Schmitz                    278.007          12.22
Dr Lucy Shapiro                                                          28.731           47.41
Sir Robert Wilson                     10.775           12.22



The Company and the directors were informed of these allocations on 4 January
2005.


S M Bicknell
Company Secretary
4 January 2005


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