Director Shareholding

GlaxoSmithKline PLC
04 January 2005



                              Directors' Interests


I give below details of changes in the directors' interests in the Ordinary
Shares and American Depository Shares (ADSs) of GlaxoSmithKline plc.



On 31 December 2004, the following non-executive Directors were provisionally
allocated the following awards over Ordinary Shares and ADSs in the Company
under the share allocation arrangements for non-executive Directors for the
period of service from 1 October to 31 December 2004, as listed below.


Non Executive Director         Ordinary Shares        American Depository Shares
                                                              (ADS)
Sir Christopher Hogg               4,568.74
Sir Christopher Gent               1,227.50
Mr Lawrence Culp                                              574.66
Mr Crispin Davis                   1,227.50
Sir Peter Job                      1,227.50
Sir Deryck Maughan                                            574.66
Sir Ian Prosser                      920.62
Dr Ronaldo Schmitz                   736.50
Dr Lucy Shapiro                                               143.66
Sir Robert Wilson                    409.17


The Company and the directors were informed of these allocations on 4 January
2005.


S M Bicknell
Company Secretary
4 January 2005




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