Director Shareholding

GlaxoSmithKline PLC
04 January 2005



Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc:


The Administrators of the GlaxoSmithKline US Retirement Savings Plan ("the
Plan") notified GlaxoSmithKline plc on 03 January 2005, that as a result of a
movement in the fund on 31 December 2004, the number of Ordinary Share ADRs held
by the fund had changed from 18,699,989 to 18,630,305 at an average price of
$46.55


The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Dr T Yamada are therefore potentially
interested in the shares held in the fund from time to time in the same way as
other employees or former employees of GlaxoSmithKline plc and its subsidiaries.



S M Bicknell
Company Secretary



04 January 2005


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