Director Shareholding

GlaxoSmithKline PLC
05 November 2004





                              Director's Interests

Following a re-valuation of the cash element of the notional investment held
within the US Retirement Savings Plan, which is notionally held in GSK Ordinary
Share ADRs, the Administrators of the Plan notified GlaxoSmithKline plc and the
under-mentioned Directors on 5 November 2004 of an increase in the notional
allocation of Ordinary Share ADRs on 4 November 2004 at a price of $44.37 per
share:-




   Dr J P Garnier                                        44
   Dr T Yamada                                           15



S M Bicknell

Company Secretary

5 November 2004




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