Director Shareholding

GlaxoSmithKline PLC
22 November 2004



Director's Interests





I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.




16 November 2004           The Administrators of the SmithKline Beecham Employee Benefit Trust ("the
                           Trust") notified the Company on 22 November 2004 that 583 Ordinary shares in
                           the Company had been sold on 16 November 2004 on behalf of participants in the
                           GlaxoSmithKline Annual Investment Plan.



                           The Trust also notified the Company on 22 November that 1,917 Ordinary Shares
                           had been transferred to participants of the Annual Investment Plan.



                           The Trust notified the Company on 22 November 2004 that 522 Ordinary shares in
                           the Company had been sold on 17 November 2004 on behalf of a participant in
                           the SmithKline Beecham Bonus Investment Plan.



                           The Administrators of the Trust notified the Company on 22 November 2004 that
                           1729 Ordinary shares had been transferred from the Trust to a participant in
17 November 2004           the SmithKline Beecham Bonus Investment Plan.









The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, John Coombe is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.







S M Bicknell

Company Secretary



22 November 2004




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