Director Shareholding

GlaxoSmithKline PLC
31 August 2004


Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc:


          The Administrators of the GlaxoSmithKline US Retirement Savings Plan 
          ("the Plan") notified GlaxoSmithKline plc on 30 August 2004, that as a 
          result of a movement in the fund on 27 August 2004, the number of 
          Ordinary Share ADRs held by the fund had changed from 19,127,076 to 
          19,223,894 at an average price of $40.94.

The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Dr T Yamada are therefore potentially
interested in the shares held in the fund from time to time in the same way as
other employees or former employees of GlaxoSmithKline plc and its subsidiaries.

S M Bicknell

Company Secretary


31 August 2004

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