Director Shareholding

GlaxoSmithKline PLC
10 September 2004


                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.
                         
8 September 2004         Abacus (GSK) Trustees Limited, as trustee of the
                         GlaxoSmithKline Employee Trust, ("the GSK Trust"), 
                         transferred 1,128 Ordinary Shares in the Company to a 
                         participant in the SmithKline Beecham Mid Term 
                         Incentive Plan.


8 September 2004         Abacus (GSK) Trustees Limited, as trustee of the GSK 
                         Trust, sold 784 Ordinary Shares in the Company on 
                         behalf of a participant in the SmithKline Beecham Mid 
                         Term Incentive Plan at a price of £11.41099 per 
                         Ordinary share.

The Company was advised of these transactions on 10 September 2004.

The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J D Coombe are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.

S M Bicknell

Company Secretary


10 September 2004


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