Director Shareholding

GlaxoSmithKline PLC
10 August 2004



                              Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.




9 August 2004      Abacus Corporate Trustee Limited as trustee of the
                   GlaxoSmithKline (US)  Trust, ("GSK US Trust"), transferred
                   122 American Depositary Receipts in the Company to a
                   participant in the GSK Performance Share Plan.


The Company was advised of this transaction on 10 August 2004.


The GSK US Trust is a grantor trust of which all employees or former employees
of SmithKline Beecham Corporation and its subsidiaries are potential
beneficiaries.  Two of the Company's directors, Dr J-P Garnier and Dr T Yamada
are therefore interested in the shares held in the GSK US Trust from time to
time in the same way as other employees or former employees of SmithKline
Beecham Corporation and its subsidiaries.





S M Bicknell
Company Secretary


10 August 2004


                      This information is provided by RNS
            The company news service from the London Stock Exchange