Director Shareholding

GlaxoSmithKline PLC
01 October 2004






                              Directors Interests





I give below details of a change in the interests in Ordinary Shares of
GlaxoSmithKline plc in respect of the under-mentioned Director arising from the
purchase of Ordinary Shares at a price of £12.20 per Ordinary Share on 30
September 2004 through the Company's ShareReward Plan ("the Plan") which Mr
Coombe entered on 5 October 2001:




Mr J D Coombe                    Acquisition of 5 Ordinary Shares under the 
                                 Dividend Reinvestment element of the Plan



Mr Coombe and the Company were advised of this information on 1 October 2004.







S M Bicknell

Company Secretary



1 October 2004


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