Director Shareholding

GlaxoSmithKline PLC
09 July 2004

                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc:

The Administrators of the GlaxoSmithKline US Retirement Savings Plan ("the
Plan") notified GlaxoSmithKline plc on 9 July 2004, that as a result of a
movement in the fund on 8 July 2004, the number of Ordinary Share ADRs held by
the fund had changed from 19,032,373 to 19,041,528 at an average price of
$41.23.

The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Dr T Yamada are therefore potentially
interested in the shares held in the fund from time to time in the same way as
other employees or former employees of GlaxoSmithKline plc and its subsidiaries.


S M Bicknell
Company Secretary

9 July 2004


                      This information is provided by RNS
            The company news service from the London Stock Exchange