Director Shareholding

GlaxoSmithKline PLC
28 April 2004

                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

26 April 2004               The Administrators of the SmithKline Beecham 
                            Employee Benefit Trust ("the Trust") notified the 
                            Company on 28 April 2004 that following reinvestment
                            of the cash dividend paid to the shareholders on 
                            15 April 2004 1,760 Ordinary Shares in the Company 
                            had been purchased for participants in the
                            SmithKline Beecham Bonus Investment Plan at a price 
                            of £11.6575.

                            The Trust also notified the Company on 28 April 2004 
                            that following reinvestment of the cash dividend 
                            paid to shareholders on 15 April 2004, 7,227 
                            Ordinary Shares in the Company had been purchased 
                            for participants in the GlaxoSmithKline Annual 
                            Investment Plan at a price of £11.66. The Trust
                            also notified the Company on 28 April that 5,647 
                            Ordinary Shares had been transferred to a 
                            participant of the Annual Investment Plan.

The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, John Coombe is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.


S M Bicknell

Company Secretary


28 April 2004



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