Director Shareholding

GlaxoSmithKline PLC
09 June 2004





                              Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.




    Abacus (GSK) Trustees Limited, as trustee of the GlaxoSmithKline Employee Trust, ("GSK Trust"),
    transferred 45,517 Ordinary Shares in the Company to participants in the SmithKline Beecham Employee
    Share Option Plan 1991 on 1 May 2003.  The Trustees also transferred 11,276 Ordinary Shares in the
    Company to participants in the SmithKline Beecham Employee Share Option Plan 1991 on 30 June 2003,
    46,460 Ordinary Shares in the Company to participants in the SmithKline Beecham Employee Share Option
    Plan 1991 on 5 September 2003, 4,382 Ordinary Shares in the Company to participants in the SmithKline
    Beecham Employee Share Option Plan on 2 December 2003 and 626 Ordinary Shares in the Company to
    participants in the SmithKline Beecham Employee Share Option Plan 1991 on 5 April 2004.





The Company was advised of these transactions on 8 June 2004.



The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J D Coombe are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.



S M Bicknell

Company Secretary

9 June 2004


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