Director Shareholding

GlaxoSmithKline PLC
14 April 2004



                              Director's Interests



I give below details of a change in the interests in Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned Director arising from the
purchase of Ordinary Shares at a price of £11.06 per Ordinary Share on 13 April
2004 through the Company's ShareReward Plan ("the Plan") which Mr Coombe entered
on 5 October 2001:


Mr J D Coombe                      Acquisition of 11 Ordinary Shares under the partnership element of the
                                   Plan (personal contribution)

                                   Acquisition of 11 Ordinary Shares under the matching element of the Plan
                                   (Company contribution)

Mr Coombe and the Company were advised of this information on 14 April 2004.

S M Bicknell

Company Secretary


14 April 2004

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