Director Shareholding

GlaxoSmithKline PLC
08 January 2004

                              Directors Interests



I give below details of a change in the interests in Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned Director arising from the
purchase of Ordinary Shares at a price of £12.60 per Ordinary Share on 6 January
2004 through the Company's ShareReward Plan ("the Plan") which Mr Coombe entered
on 5 October 2001:



Mr J D Coombe                      Acquisition of 3 Ordinary Shares under the 
                                   Dividend Reinvestment element of the Plan

Mr Coombe and the Company were advised of this information on 8 January 2004.






S M Bicknell

Company Secretary


8 January 2004


                      This information is provided by RNS
            The company news service from the London Stock Exchange