Director Shareholding

GlaxoSmithKline PLC
07 January 2004

                              Directors' Interests



I give below details of changes in interests in the Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned Directors or connected
persons, arising from the purchase of Ordinary Shares on 6 January 2004 under a
Single Company ISA at a price of £12.61 per Ordinary Share:

Mr J D Coombe                                                              3

Mrs G A Coombe                                                             3
(wife of Mr J D Coombe)
Sir Peter Job                                                              5




The Company and Directors were advised of this information on 7 January 2004.








S M Bicknell

Company Secretary


7 January 2004



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