Director Shareholding

GlaxoSmithKline PLC
23 February 2004


                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

19 February 2004             Abacus (GSK) Trustees Limited, as trustee of the
                             GlaxoSmithKline Employee Trust, ("GSK Trust"),
                             transferred 227,586 Ordinary Shares in the Company
                             to participants in the SmithKline Beecham Employee
                             Share Option Plan 1991.

                             Abacus (GSK) Trustees Limited, as trustee of the
                             GSK Trust, sold 761 Ordinary Shares in the Company
                             on behalf of participants in the SmithKline Beecham
                             Mid-Term Incentive Plan at a price of £11.2610 per
                             share.

                             Abacus (GSK) Trustees Limited, as trustee of the
                             GSK Trust, transferred 1,093 Ordinary Shares in the
                             Company to participants in the SmithKline Beecham
                             Mid-Term Incentive Plan.

The Company was advised of these transactions on 20 February 2004.


The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J D Coombe are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.


S M Bicknell

Company Secretary

23 February 2004


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