Director Shareholding

GlaxoSmithKline PLC
19 December 2003

                              Director's Interests

I give below details of changes in director's interests in the Ordinary Shares
of GlaxoSmithKline plc.


          The Administrators of the GlaxoSmithKline US Retirement
          Savings Plan ("the Plan") notified GlaxoSmithKline plc on 19
          December 2003, that as a result of movement in the fund on
          17 December 2003, the number of Ordinary Share ADRs held by
          the fund had decreased from 18,764,201 to 18,698,529 at an
          average price of $45.51.




The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. One of the
Company's directors, Dr J P Garnier is therefore potentially interested in the
shares held in the fund from time to time in the same way as other employees or
former employees of GlaxoSmithKline plc and its subsidiaries.




S M Bicknell

Company Secretary


19 December 2003


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