Director Shareholding

GlaxoSmithKline PLC
08 October 2003



                             Directors' Interests

I give below details of changes in interests in the Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned Directors or connected
persons, arising from the purchase of Ordinary Shares on 2 October 2003 under a
Single Company ISA at a price of £12.66 per Ordinary Share:

Mr J D Coombe                                                              4

Mrs G A Coombe                                                             4
(wife of Mr J D Coombe)

Sir Peter Job                                                              6


The Company and Directors were advised of this information on 8 October 2003.


S M Bicknell
Company Secretary

8 October 2003



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