Director Shareholding

GlaxoSmithKline PLC
17 November 2003

                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

14 November 2003             Abacus (GSK) Trustees Limited, as trustee of the
                             GlaxoSmithKline Employee Trust, ("GSK Trust"),
                             transferred 4,005 Ordinary shares in the Company to
                             participants in the SmithKline Beecham Employee
                             Share Option Plan 1991.

                             Abacus (GSK) Trustees Limited, as trustee of the
                             GSK Trust, transferred 89,870 Ordinary Shares in
                             the Company to participants in the SmithKline
                             Beecham Employee Share Option Plan 1991.

The Company was advised of these transactions on 17 November 2003.

The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Two of the Company's directors, Dr J-P Garnier and Mr J D Coombe
are therefore interested in the shares held in the GSK Trust from time to time
in the same way as other employees or former employees of GlaxoSmithKline plc
and its subsidiaries.


S M Bicknell

Company Secretary


17 November 2003


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