Director Shareholding

GlaxoSmithKline PLC
10 September 2003

                              Director's Interests



I give below details of a change in the interests in Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned Director arising from the
purchase of Ordinary Shares at a price of £12.54 per Ordinary Share on 9
September 2003 through the Company's ShareReward Plan ("the Plan") which Mr
Coombe entered on 5 October 2001:



Mr J D Coombe                      Acquisition of 10 Ordinary Shares under the 
                                   partnership element of the Plan (personal 
                                   contribution)

                                   Acquisition of 10 Ordinary Shares under the 
                                   matching element of the Plan (Company 
                                   contribution)



Mr Coombe and the Company were advised of this information on 10 September 2003.






S M Bicknell

Company Secretary


10 September 2003


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