Director Shareholding

GlaxoSmithKline PLC
08 April 2003


                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


4 April 2003      The Administrators of the SmithKline Beecham Employee
                  Benefit Trust ("the Trust") notified the Company on 8 April
                  2003 that 37,964 Ordinary shares had been transferred from
                  the Trust to participants of the SmithKline Beecham 1991
                  Share Option Plan.

                  The Trust also sold 225 ordinary shares on 2 April 2003 at
                  a price of £11.65 per share.

                  The Administrators of the Trust, also notified the Company
                  on 8 April 2003 that 101 Ordinary shares had been
                  transferred back into the Trust following the incorrect
                  transfer of those shares to a participant in the Mid Term
                  Incentive Plan.

The Trust is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and John Coombe are therefore interested in
the shares held in the fund from time to time in the same way as other employees
or former employees of GlaxoSmithKline plc and its subsidiaries.


S M Bicknell
Company Secretary
8 April 2003


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