Director Shareholding

GlaxoSmithKline PLC
01 April 2003



                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



31 March 2003              Abacus (GSK) Trustees Limited, as trustee of the
                           GlaxoSmithKline Employee Trust, ("the GSK Trust"),
                           sold 1,648 Ordinary Shares in the Company at a price
                           of £11.1555 per Ordinary Share on behalf of a
                           participant of the Glaxo Wellcome 1999 Long Term
                           Incentive Plan.

                           Abacus (GSK) Trustees Limited, as trustee of the
                           GlaxoSmithKline Employee Trust, ("the GSK Trust"),
                           sold 1,528 Ordinary Shares in the Company at a price
                           of £11.2035 per Ordinary Share on behalf of a
                           participant of the Glaxo Wellcome 1999 Long Term
                           Incentive Plan.

                           Abacus (GSK) Trustees Limited, as trustee of the
                           GlaxoSmithKline Employee Trust, ("the GSK Trust"),
                           transferred 11,300 Ordinary Shares in the Company on
                           behalf of participants of the Glaxo Wellcome 1999
                           Long Term Incentive Plan.


The Company was advised of these transactions on 1 April 2003.


The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Two of the Company's directors, Dr J-P Garnier and Mr J D Coombe
are therefore interested in the shares held in the GSK Trust from time to time
in the same way as other employees or former employees of GlaxoSmithKline plc
and its subsidiaries.


S M Bicknell

Company Secretary


1 April 2003


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