Director Shareholding

GlaxoSmithKline PLC
05 March 2003



                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



3 March 2003               Abacus (GSK) Trustees Limited, as trustee of the
                           GlaxoSmithKline Employee Trust, ("the GSK Trust"),
                           sold 1,648 Ordinary Shares in the Company at a price
                           of £11.4335 per Ordinary Share.

                           Abacus (GSK) Trustees Limited, as trustee of the
                           GlaxoSmithKline Employee Trust, ("the GSK Trust"),
                           sold 5,453 Ordinary Shares in the Company at a price
                           of £11.43 per Ordinary Share.

                           Abacus (GSK) Trustees Limited, as trustee of the
                           GlaxoSmithKline Employee Trust, ("the GSK Trust"),
                           transferred 7,677 Ordinary Shares in the Company to
                           participants of the Glaxo Wellcome 1999 Long Term
                           Incentive Plan.




The Company was advised of this transaction on 4 March 2003.


The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Two of the Company's directors, Dr J-P Garnier and Mr J D Coombe
are therefore interested in the shares held in the GSK Trust from time to time
in the same way as other employees or former employees of GlaxoSmithKline plc
and its subsidiaries.


S M Bicknell

Company Secretary


5 March 2003


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