Director Shareholding

GlaxoSmithKline PLC
25 March 2003



                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


25 March 2003                The Administrators of the SmithKline Beecham Employee Benefit Trust ("the
                             Trust") notified the Company on the 25 March 2003 that the Trust purchased
                             299,458 Ordinary shares for participants in the GlaxoSmithKline Annual
                             Investment Plan at a price of £11.41 per share.



The Trust is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and John Coombe are therefore interested in
the shares held in the fund from time to time in the same way as other employees
or former employees of GlaxoSmithKline plc and its subsidiaries.





S M Bicknell
Company Secretary
25 March 2003


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