Director Shareholding

GlaxoSmithKline PLC
26 February 2003

                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



25 February 2003           Abacus (GSK) Trustees Limited, as trustee of the
                           GlaxoSmithKline Employee Trust, ("the GSK Trust"),
                           sold 60,779 Ordinary Shares in the Company at a price
                           of £11.021 per Ordinary Share.

                           Abacus (GSK) Trustees Limited, as trustee of the
                           GlaxoSmithKline Employee Trust, ("the GSK Trust"),
                           sold 1,532 Ordinary Shares in the Company at a price
                           of £11.1735 per Ordinary Share.

                           Abacus (GSK) Trustees Limited, as trustee of the
                           GlaxoSmithKline Employee Trust, ("the GSK Trust"),
                           transferred 117,320 Ordinary Shares in the Company to
                           participants of the Glaxo Wellcome 1999 Long Term
                           Incentive Plan..




The Company was advised of this transaction on 26 February 2003.


The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Two of the Company's directors, Dr J-P Garnier and Mr J D Coombe
are therefore interested in the shares held in the GSK Trust from time to time
in the same way as other employees or former employees of GlaxoSmithKline plc
and its subsidiaries.


S M Bicknell

Company Secretary


26 February 2003


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