Director Shareholding

GlaxoSmithKline PLC
02 January 2003

                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

26 December 2002   The Administrators of the GlaxoSmithKline US Retirement 
                   Savings Plan ("the Plan") notified GlaxoSmithKline plc on 
                   27 December 2002, that as a result of movement in the fund on 
                   the 26 December 2002, the number of Ordinary Share ADRs held
                   by the fund had increased from 18,284,894 to 18,343,751 at an 
                   average price of $36.60.




The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Mr J D Coombe are therefore interested
in the shares held in the fund from time to time in the same way as other
employees or former employees of GlaxoSmithKline plc and its subsidiaries.




S M Bicknell

Company Secretary


2 January 2003


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