Director Shareholding

GlaxoSmithKline PLC
12 April 2002



                              Directors' Interests

I give below details of a change in the interests in Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned Director arising from the
purchase of Ordinary Shares at a price of £16.45 per Ordinary Share on 10 April
2002 through the Company's ShareReward Plan ("the Plan") which Mr Coombe entered
on 5 October 2001:

Mr J D Coombe                      Acquisition of 8 Ordinary Shares under the 
                                   partnership element of the Plan (personal 
                                   contribution)

                                   Acquisition of 8 Ordinary Shares under the 
                                   matching element of the Plan
                                   (Company contribution)

Mr Coombe and the Company were advised of this information on 11 April 2002

S M Bicknell

Company Secretary


12 April 2002




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