Director Shareholding

GlaxoSmithKline PLC
11 December 2001


                             Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


7        The Administrators of the GlaxoSmithKline Retirement Savings Plan
December ('the Plan') notified GlaxoSmithKline plc on the 11 December 2001,
2001     that as a result of movement in the fund on the 7 December 2001, the
         number of Ordinary Share ADRs held by the fund had increased from
         18,709,266 to 18,756,344 at an average price of $50.2600

The Plan is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier is therefore, interested in the
shares held in the fund from time to time in the same way as other employees
or former employees of SmithKline Beecham plc and its subsidiaries.



S M Bicknell

Company Secretary

11 December 2001