Director Shareholding

GlaxoSmithKline PLC
11 December 2001

                             Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


10         The Trustees of the SmithKline Beecham Employee Benefit Trust ('the
December   Trust') purchased 2,508,526 Ordinary Shares in the Company at a price
2001       of £17.304463 per share.

The Company was advised of this transaction on the 11 December 2001

The Trust is a discretionary fund of which all employees or former employees
of SmithKline Beecham plc and its subsidiaries are potential beneficiaries.
One of the Company's directors, Dr J P Garnier is therefore, interested in the
shares held in the fund from time to time in the same way as other employees
or former employees of SmithKline Beecham plc and its subsidiaries.





S M Bicknell

Company Secretary

11 December 2001