Director Shareholding

GlaxoSmithKline PLC 5 December 2001 Directors' Interests I give below details of changes in directors' interests in the Ordinary Shares of GlaxoSmithKline plc. 4 Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome December Employee Trust ('the Trust'), transferred 6,138 Ordinary Shares in the 2001 Company to participants of the Glaxo Wellcome UK Share Option Scheme, the Glaxo Wellcome 1999 Share Option Plan and the Glaxo Wellcome International Share Option Scheme. The Company was advised of these transactions on 5 December 2001. The Trust is a discretionary trust of which all employees or former employees of GlaxoSmithKline Services plc (formerly Glaxo Wellcome plc) and its subsidiaries are potential beneficiaries. Two of the Company's directors, Sir Richard Sykes and John Coombe are therefore interested in the shares held in the Trust from time to time in the same way as other employees or former employees of GlaxoSmithKline Services plc and its subsidiaries. S M Bicknell Company Secretary 5 December 2001

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