Director Shareholding

GlaxoSmithKline PLC
13 December 2001


                             Directors' Interests

I give below details of a change in the interests in Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned Director arising from the
purchase of Ordinary Shares at a price of £17.455 per Ordinary Share on 11
December 2001 through the Company's ShareReward Plan ('the Plan') which Mr
Coombe entered on 5 October 2001:

Mr J D     Acquisition of 7 Ordinary Shares under the partnership element of the
Coombe     Plan (personal contribution)

           Acquisition of 7 Ordinary Shares under the matching element of the
           Plan (company contribution)


Mr Coombe and the Company were advised of this information on 12 December 2001.


S M Bicknell

Company Secretary


13 December 2001