Director Shareholding

GlaxoSmithKline PLC
29 November 2001



                             Directors' Interests


I give below details of changes in the directors' interests in the Ordinary
Shares and American Depositary Shares (ADSs) of GlaxoSmithKline plc.


On 28 November 2001, under the Rules of the GlaxoSmithKline Performance Share
Plan, Target Awards were granted over Ordinary Shares and ADSs in the Company
to the directors listed below:

                   Ordinary Shares        American Depository Shares
Dr J-P Garnier                            70,000
Mr J D Coombe      40,000




On the same day, options to acquire the Company's Shares and ADSs were granted
under the GlaxoSmithKline Share Option Plan to the directors listed below:

            Ordinary     Subscription Price American Depository  Subscription
            Shares                          Shares               Price
Dr J-P                                      450,000              $51.95
Garnier
Mr J D      290,000      £18.15
Coombe


Under the terms of the GlaxoSmithKline Performance Share Plan (which was
approved by Shareholders on 31 July 2000), Target Awards are granted annually
to eligible executives, designating a number of Shares/ADSs that may be
awarded, dependent upon the Company's performance over a three year
measurement period. The three year measurement period for the Target Awards
granted on 28 November 2001 will commence on 1 January 2002 and end on 31
December 2004.


The grant of options is made under the GlaxoSmithKline Share Option Plan which
was approved by Shareholders on 31st July 2000. A performance condition has
been set for the vesting of the options granted to the above directors.


S M Bicknell

Company Secretary


29 November 2001