Director Shareholding

GlaxoSmithKline PLC
25 September 2001

                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

24 September 2001    Abacus (GW) Trustees Limited, as trustee of The Glaxo 
                     Wellcome Employee Trust ('the Trust'), purchased 1,605,870 
                     Ordinary Shares in the Company at a price of £17.109 per 
                     share, and 2,868,783 Ordinary Shares in the Company at a 
                     price of £17.30767 per share.


The Company was advised of these transactions on 25 September 2001.

The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe are therefore
interested in the shares held in the Trust from time to time in the same way
as other employees or former employees of Glaxo Wellcome plc and its
subsidiaries.



S M Bicknell

Company Secretary


25 September 2001