Director Shareholding

GlaxoSmithKline PLC
24 September 2001

                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

21          Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome
September   Employee Trust ('the Trust'), purchased 2,954,134 Ordinary Shares in
2001        the Company at a price of £16.8244 per share, and 1,300,000 Ordinary
            Shares in the Company at a price of £17.0597 per share. The Trust
            also transferred 24,799 Ordinary Shares to participants of the Glaxo
            Wellcome International Share Option Scheme.



The Company was advised of these transactions on 24 September 2001.

The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe are therefore
interested in the shares held in the Trust from time to time in the same way
as other employees or former employees of Glaxo Wellcome plc and its
subsidiaries.



S M Bicknell

Company Secretary



24 September 2001