Director Shareholding

GlaxoSmithKline PLC
21 September 2001

                             Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

20        The Administrators of the SmithKline Beecham US Retirement Savings
September Plan ('the Plan') notified GlaxoSmithKline plc on the 21 September
2001      2001, that as a result of movement in the fund on the 20 September
          2001, the number of Ordinary Share ADRs held by the fund had
          decreased from 18,691,686 to 18,250,080 at an average price of
          $51.5500.

The Plan is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier is therefore, interested in the
shares held in the fund from time to time in the same way as other employees
or former employees of SmithKline Beecham plc and its subsidiaries.


S M Bicknell

Company Secretary

21 September 2001