Director Shareholding

GlaxoSmithKline PLC
4 October 2001


                             Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

3        Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome Employee
October  Trust ('the Trust'), transferred 4,443 Ordinary Shares in the Company
2001     to participants of the Glaxo Wellcome UK Share Option Scheme and the
         Glaxo Wellcome International Share Option Scheme. The Trust also sold
         32,334 Ordinary Shares in the Company at a price of £18.50 per share.


The Company was advised of these transactions on 4 October 2001.

The Trust is a discretionary trust of which all employees or former employees
of GlaxoSmithKline Services plc (formerly Glaxo Wellcome plc) and its
subsidiaries are potential beneficiaries. Two of the Company's directors, Sir
Richard Sykes and John Coombe are therefore interested in the shares held in
the Trust from time to time in the same way as other employees or former
employees of GlaxoSmithKline Services plc and its subsidiaries.


S M Bicknell

Company Secretary


4 October 2001