Director Shareholding

GlaxoSmithKline PLC
1 October 2001



                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

28 September 2001   Abacus (GW) Trustees Limited, as trustee of The Glaxo       
                    Wellcome Employee Trust ('the Trust'), purchased 810,104    
                    Ordinary Shares in the Company at a price of £19.151 per    
                    share, and transferred 13,482 Ordinary Shares to            
                    participants of the Glaxo Wellcome International Share      
                    Option Scheme.


The Company was advised of these transactions on 1 October 2001.


The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe are therefore
interested in the shares held in the Trust from time to time in the same way
as other employees or former employees of Glaxo Wellcome plc and its
subsidiaries.




S M Bicknell
Company Secretary



1 October 2001